RAF1

Across TCGA patient cohorts, RAF1 mutation is significantly associated with the RNA expression of many other genes, with 3,872 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RAF1-associated genes across cancer lineages are IFI27L1, POLG, and BTBD6. Each is linked with RAF1 in more than 2 cancer types. Because this analysis shows association rather than direction, both RAF1-to-partner and partner-to-RAF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IFI27L1 grouped by RAF1-low versus RAF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAF1→partner) and Y-score (partner→RAF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IFI27L1 →	+0.401	+1.716	.003	.004	3	3
UCEC	POLG →	+0.478	+2.364	<.001	.002	3	3
UCEC	BTBD6 →	+0.294	+2.137	.006	.009	3	3
UCEC	TMEM269 →	+0.204	+2.241	<.001	.001	3	2
UCEC	UHRF1 →	+0.806	+2.332	<.001	<.001	3	2
BLCA	NFILZ →	+0.179	+5.411	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,872 associations by consensus.

IFI27L1 by RAF1 expression — UCEC

Explore this box plot interactively →