RAF1

Across TCGA cell cohorts, RAF1 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible RAF1-associated genes across cancer lineages are NKX2-6, TLE7, and OR1L1. Each is linked with RAF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RAF1-to-partner and partner-to-RAF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NKX2-6 grouped by RAF1-low versus RAF1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAF1→partner) and Y-score (partner→RAF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	NKX2-6 →	+0.591	+5.201	<.001	.006	3	1
BLOOD_Leukemia	TLE7 →	+0.042	+5.969	<.001	.001	3	1
OVARY	OR1L1 →	+0.022	+5.196	<.001	.005	3	1
OVARY	OR10AG1 →	+0.020	+5.807	<.001	.001	3	1
UPPER_AERODIGESTIVE_TRACT	PRR23C →	+0.006	+4.736	<.001	.009	3	1
BREAST	BMP15 →	+0.016	+5.781	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

NKX2-6 by RAF1 expression — BLOOD_Leukemia

Explore this box plot interactively →