Across TCGA pan-cancer cohorts, RAET1E-AS1 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of RAET1E-AS1’s most consistent transcriptional readouts.
The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where RAET1E-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types RAET1E-AS1 is over-expressed in tumor, although a few such as HNSC and KIRP show the opposite, repressed pattern.
HNSC, THCA, and KIRP are the cancer types where RAET1E-AS1 tumor–normal differential expression is most reproducible.