RADX

Across TCGA patient cohorts, RADX mutation is significantly associated with the RNA expression of many other genes, with 4,502 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RADX-associated genes across cancer lineages are MIR615, IGHD2-15, and AATF. Each is linked with RADX in more than 2 cancer types. Because this analysis shows association rather than direction, both RADX-to-partner and partner-to-RADX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR615 grouped by RADX-low versus RADX-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RADX→partner) and Y-score (partner→RADX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR615 →	+0.176	+1.428	<.001	.007	3	3
UCEC	IGHD2-15 →	+1.059	+1.371	<.001	<.001	3	3
UCEC	AATF →	+0.341	+1.621	<.001	<.001	3	3
BLCA	IGKV2OR2-8 →	+0.167	+3.836	<.001	.003	3	3
UCEC	SNW1 →	+0.314	+1.794	.003	<.001	3	3
UCEC	AFG3L2 →	+0.357	+2.021	.004	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,502 associations by consensus.

MIR615 by RADX expression — UCEC

Explore this box plot interactively →