RADX

Across TCGA patient cohorts, RADX mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RADX-associated genes across cancer lineages are Shc_pY317, Tuberin_pT1462, and 14-3-3_beta. Each is linked with RADX in more than 1 cancer types. Because this analysis shows association rather than direction, both RADX-to-partner and partner-to-RADX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Shc_pY317 grouped by RADX-low versus RADX-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RADX→partner) and Y-score (partner→RADX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Shc_pY317 →	-0.123	-1.523	.002	.006	3	2
UCEC	Tuberin_pT1462 →	+0.166	+0.953	.007	.037	3	2
UCEC	14-3-3_beta →	-0.082	-1.899	.002	.004	3	1
UCEC	ERK2 →	+0.146	+1.473	.004	.005	3	1
UCEC	FoxM1 →	+0.151	+1.192	.029	.007	3	1
UCEC	Gab2 →	+0.247	+1.047	.009	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

Shc_pY317 by RADX expression — UCEC

Explore this box plot interactively →