RADX

Across TCGA cell cohorts, RADX RNA expression is significantly associated with the go_rna of many other GO terms, with 2,666 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RADX-associated GO terms across cancer lineages are Response to ionizing radiation, Positive regulation of DNA-directed DNA polymerase activity, and Mitotic DNA damage checkpoint signaling. Each is linked with RADX in more than 8 cancer types. Because this analysis shows association rather than direction, both RADX-to-partner and partner-to-RADX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Response to ionizing radiation grouped by RADX-low versus RADX-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RADX→partner) and Y-score (partner→RADX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Response to ionizing radiation →	+0.052	+1.164	.003	.007	3	9
OESOPHAGUS	Positive regulation of DNA-directed DNA polymerase activity →	+0.132	+1.156	.002	.007	3	8
LUNG_SCLC	Mitotic DNA damage checkpoint signaling →	+0.051	+2.323	.002	.005	3	8
LUNG_SCLC	Regulation of microtubule cytoskeleton organization →	+0.060	+2.463	<.001	<.001	3	8
LARGE_INTESTINE	DNA recombination →	+0.046	+1.138	<.001	<.001	3	8
LARGE_INTESTINE	Recombinational repair →	+0.045	+1.106	.002	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,666 associations by consensus.

Response to ionizing radiation by RADX expression — OESOPHAGUS

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