RADX

Across TCGA cell cohorts, RADX mutation is significantly associated with the drug of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RADX-associated genes across cancer lineages are LMB_AB3, 150412, and IAP_5620. Each is linked with RADX in more than 1 cancer types. Because this analysis shows association rather than direction, both RADX-to-partner and partner-to-RADX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LMB_AB3 grouped by RADX-low versus RADX-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RADX→partner) and Y-score (partner→RADX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	LMB_AB3 →	+0.393	+2.649	.027	.046	3	1
LARGE_INTESTINE	150412 →	+0.423	+2.777	.011	.038	3	1
LARGE_INTESTINE	IAP_5620 →	+0.420	+2.649	.022	.046	2	1
LARGE_INTESTINE	IWP-2 →	+0.274	+2.893	.039	.034	1	1
LARGE_INTESTINE	GSK2276186C →	+0.490	+2.649	.034	.046	1	1
LARGE_INTESTINE	Mitoxantrone →	+0.624	+2.649	.037	.046	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

LMB_AB3 by RADX expression — LARGE_INTESTINE

Explore this box plot interactively →