RAD9B

Across TCGA patient cohorts, RAD9B mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RAD9B-associated genes across cancer lineages are 14-3-3_beta, INPP4B, and JNK2. Each is linked with RAD9B in more than 1 cancer types. Because this analysis shows association rather than direction, both RAD9B-to-partner and partner-to-RAD9B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by RAD9B-low versus RAD9B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAD9B→partner) and Y-score (partner→RAD9B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.085	-1.571	.032	.036	3	1
UCEC	INPP4B →	-0.297	-2.321	.019	.033	3	1
UCEC	JNK2 →	+0.203	+2.000	.009	.010	3	1
UCEC	MEK1 →	+0.461	+2.906	.001	.001	3	1
UCEC	NDRG1_pT346 →	-0.425	-2.459	.027	.018	3	1
UCEC	p27_pT198 →	+0.099	+2.321	.018	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

14-3-3_beta by RAD9B expression — UCEC

Explore this box plot interactively →