RAD54L2

Across TCGA patient cohorts, RAD54L2 mutation is significantly associated with the RNA expression of many other genes, with 5,776 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RAD54L2-associated genes across cancer lineages are SEC13, SKA1, and PIMREG. Each is linked with RAD54L2 in more than 3 cancer types. Because this analysis shows association rather than direction, both RAD54L2-to-partner and partner-to-RAD54L2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SEC13 grouped by RAD54L2-low versus RAD54L2-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAD54L2→partner) and Y-score (partner→RAD54L2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	SEC13 →	+0.387	+3.195	.005	.009	3	4
UCEC	SKA1 →	+0.811	+2.055	<.001	<.001	3	4
UCEC	PIMREG →	+0.704	+2.065	<.001	<.001	3	4
BLCA	SERBP1P2 →	+0.078	+3.536	.001	<.001	3	4
UCEC	NDC80 →	+0.498	+1.653	.006	<.001	3	4
SKCM	RRP9 →	+0.380	+2.874	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,776 associations by consensus.

SEC13 by RAD54L2 expression — STAD

Explore this box plot interactively →