RAD54L2

Across TCGA patient cohorts, RAD54L2 mutation is significantly associated with the total protein of many other genes, with 68 significant associations in total. COAD shows the largest number of these associations.

The most reproducible RAD54L2-associated genes across cancer lineages are Cyclin-E2, S6_pS240_S244, and Caspase-7-cleavedD198. Each is linked with RAD54L2 in more than 3 cancer types. Because this analysis shows association rather than direction, both RAD54L2-to-partner and partner-to-RAD54L2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-E2 grouped by RAD54L2-low versus RAD54L2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAD54L2→partner) and Y-score (partner→RAD54L2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-E2 →	+0.124	+1.415	.018	.010	3	4
UCEC	S6_pS240_S244 →	+0.327	+2.472	.009	.010	3	3
COAD	Caspase-7-cleavedD198 →	+1.338	+2.824	<.001	.034	3	3
COAD	Chk1 →	+0.544	+3.330	<.001	.005	3	3
STAD	Bad_pS112 →	-0.238	-3.000	.021	.034	3	2
COAD	EGFR_pY1068 →	-0.428	-3.309	.005	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 68 associations by consensus.

Cyclin-E2 by RAD54L2 expression — UCEC

Explore this box plot interactively →