RAD51B

Across TCGA pan-cancer cohorts, RAD51B mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated RAD51B data layer compared with 24 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher RAD51B mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated RAD51B expression acts as an unfavorable survival marker, although some lineages such as UCEC and LSCC show a favorable association.

HNSC, LUAD, and UCEC are the cancer types where RAD51B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	III,IV	0.600	0.942	<.001	47	view →
LUAD	DFS	Quartile	All	0.409	0.896	.032	3	view →
UCEC	DFS	Median	All	1.000	0.921	.045	2	view →
LSCC	OS	Tertile	II,III,IV	1.000	0.775	.042	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

RAD51B–HNSC (DFS)

Open the HNSC breakdown →