RAD51B

Across TCGA patient cohorts, RAD51B mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RAD51B-associated genes across cancer lineages are eIF4E, A-Raf_pS299, and FOXO3a_pS318_S321. Each is linked with RAD51B in more than 1 cancer types. Because this analysis shows association rather than direction, both RAD51B-to-partner and partner-to-RAD51B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by RAD51B-low versus RAD51B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAD51B→partner) and Y-score (partner→RAD51B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.176	+3.335	.020	.005	3	1
UCEC	A-Raf_pS299 →	-0.104	-2.700	.015	.006	3	1
UCEC	FOXO3a_pS318_S321 →	-0.108	-1.990	.016	.009	3	1
UCEC	MEK1 →	+0.425	+3.000	.001	<.001	3	1
UCEC	mTOR_pS2448 →	-0.150	-1.925	.005	.005	3	1
UCEC	Notch1 →	+0.169	+2.598	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

eIF4E by RAD51B expression — UCEC

Explore this box plot interactively →