RAD51

Across TCGA patient cohorts, RAD51 mutation is significantly associated with the RNA expression of many other genes, with 241 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RAD51-associated genes across cancer lineages are RN7SKP289, MTND5P22, and TSPY16P. Each is linked with RAD51 in more than 1 cancer types. Because this analysis shows association rather than direction, both RAD51-to-partner and partner-to-RAD51 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP289 grouped by RAD51-low versus RAD51-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAD51→partner) and Y-score (partner→RAD51) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RN7SKP289 →	+0.164	+5.064	<.001	.004	3	2
PRAD	MTND5P22 →	+0.604	+7.939	<.001	.008	3	2
UCEC	TSPY16P →	+0.038	+5.481	<.001	<.001	3	2
BLCA	RNU6-405P →	+0.368	+8.051	<.001	<.001	3	2
BLCA	OR8X1P →	+0.057	+5.411	.001	.005	3	2
UCEC	KMT5AP1 →	+0.265	+2.681	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 241 associations by consensus.

RN7SKP289 by RAD51 expression — BRCA

Explore this box plot interactively →