RAD51

Across TCGA patient cohorts, RAD51 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RAD51-associated genes across cancer lineages are Myosin-IIa_pS1943, p62 Lck ligand, and PKC-a. Each is linked with RAD51 in more than 1 cancer types. Because this analysis shows association rather than direction, both RAD51-to-partner and partner-to-RAD51 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Myosin-IIa_pS1943 grouped by RAD51-low versus RAD51-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAD51→partner) and Y-score (partner→RAD51) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Myosin-IIa_pS1943 →	+0.206	+3.472	.047	.002	3	1
UCEC	p62 Lck ligand →	+0.504	+3.459	.002	.005	3	1
UCEC	PKC-a →	+0.462	+2.820	.023	.035	3	1
UCEC	AMPK_pT172 →	+0.545	+3.472	.008	.002	3	1
UCEC	Rb_pS807_S811 →	-0.470	-3.459	.020	.005	3	1
UCEC	Shc_pY317 →	-0.174	-2.321	.022	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

Myosin-IIa_pS1943 by RAD51 expression — UCEC

Explore this box plot interactively →