RAD50

Across TCGA pan-cancer cohorts, RAD50 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated RAD50 data layer compared with 23 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher RAD50 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated RAD50 expression acts as an unfavorable survival marker, although some lineages such as LUAD and OV show a favorable association.

UCEC, LUAD, and OV are the cancer types where RAD50 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	III,IV	0.270	1.000	.007	28	view →
LUAD	DFS	Median	II,III,IV	0.968	0.705	.012	10	view →
OV	DFS	Quartile	All	1.000	0.768	.033	8	view →
CCRCC	DFS	Median	All	0.729	0.867	.033	4	view →
PDAC	DFS	Median	IV	0.766	0.234	.026	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

RAD50–UCEC (DFS)

Open the UCEC breakdown →