RAD50

Across TCGA cell cohorts, RAD50 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,742 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible RAD50-associated GO terms across cancer lineages are R-loop processing, Negative regulation of telomere capping, and Regulation of mitotic recombination. Each is linked with RAD50 in more than 14 cancer types. Because this analysis shows association rather than direction, both RAD50-to-partner and partner-to-RAD50 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, R-loop processing grouped by RAD50-low versus RAD50-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RAD50→partner) and Y-score (partner→RAD50) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	R-loop processing →	+0.097	+0.631	<.001	<.001	3	15
CNS	Negative regulation of telomere capping →	+0.121	+0.787	<.001	<.001	3	14
LIVER	Regulation of mitotic recombination →	+0.175	+0.861	<.001	.007	3	13
UPPER_AERODIGESTIVE_TRACT	Mitotic recombination →	+0.084	+0.807	<.001	<.001	3	13
LUNG_NSCLC_LUSC	Regulation of establishment of cell polarity →	+0.094	+1.032	.001	.008	2	13
LIVER	Microtubule polymerization →	+0.121	+0.716	.004	.009	2	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,742 associations by consensus.

R-loop processing by RAD50 expression — LUNG_SCLC

Explore this box plot interactively →