RAD50

Across TCGA cell cohorts, RAD50 mutation is significantly associated with the RNA expression of many other genes, with 243 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RAD50-associated genes across cancer lineages are KIFC2, OR52H1, and BCDIN3D. Each is linked with RAD50 in more than 1 cancer types. Because this analysis shows association rather than direction, both RAD50-to-partner and partner-to-RAD50 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KIFC2 grouped by RAD50-low versus RAD50-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAD50→partner) and Y-score (partner→RAD50) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	KIFC2 →	+0.893	+3.212	.006	.006	3	2
LARGE_INTESTINE	OR52H1 →	+0.021	+2.347	<.001	.007	3	2
LARGE_INTESTINE	BCDIN3D →	+0.653	+3.299	<.001	.004	3	2
BLOOD_Leukemia	ZNF232 →	+1.173	+3.489	.001	.001	3	2
SOFT_TISSUE	DEFA4 →	+0.056	+5.977	<.001	.001	3	1
SOFT_TISSUE	KRT26 →	+0.032	+4.930	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 243 associations by consensus.

KIFC2 by RAD50 expression — LARGE_INTESTINE

Explore this box plot interactively →