RAD21

Across TCGA cell cohorts, RAD21 mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RAD21-associated genes across cancer lineages are ITIH6, TNFSF18, and PAMR1. Each is linked with RAD21 in more than 1 cancer types. Because this analysis shows association rather than direction, both RAD21-to-partner and partner-to-RAD21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ITIH6 grouped by RAD21-low versus RAD21-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAD21→partner) and Y-score (partner→RAD21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ITIH6 →	+0.014	+3.111	.001	.003	3	1
BLOOD_Leukemia	TNFSF18 →	+0.070	+4.025	<.001	<.001	3	1
BLOOD_Leukemia	PAMR1 →	+0.082	+3.562	.003	.007	3	1
BLOOD_Leukemia	LYZL2 →	+0.012	+3.984	<.001	.006	3	1
BLOOD_Leukemia	OR10G3 →	+0.014	+3.464	<.001	.003	3	1
BLOOD_Leukemia	ALOX15B →	+0.214	+3.632	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

ITIH6 by RAD21 expression — BLOOD_Leukemia

Explore this box plot interactively →