RAD18

Across TCGA patient cohorts, RAD18 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RAD18-associated genes across cancer lineages are Caspase-7-cleavedD198, 14-3-3_beta, and Notch1. Each is linked with RAD18 in more than 1 cancer types. Because this analysis shows association rather than direction, both RAD18-to-partner and partner-to-RAD18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by RAD18-low versus RAD18-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAD18→partner) and Y-score (partner→RAD18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.025	+2.815	.018	.036	3	2
UCEC	14-3-3_beta →	-0.103	-2.432	.016	.018	3	2
UCEC	Notch1 →	+0.197	+2.472	<.001	.010	3	2
UCEC	PDCD4 →	-0.551	-2.999	.005	.035	3	2
UCEC	ATM →	-0.466	-2.222	.015	.011	3	2
UCEC	C-Raf →	+0.125	+1.700	.040	.044	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

Caspase-7-cleavedD198 by RAD18 expression — COAD

Explore this box plot interactively →