RAD18

Across TCGA cell cohorts, RAD18 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,785 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RAD18-associated GO terms across cancer lineages are Negative regulation of mitotic sister chromatid separation, Negative regulation of sister chromatid segregation, and Negative regulation of mitotic sister chromatid segregation. Each is linked with RAD18 in more than 18 cancer types. Because this analysis shows association rather than direction, both RAD18-to-partner and partner-to-RAD18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of mitotic sister chromatid separation grouped by RAD18-low versus RAD18-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RAD18→partner) and Y-score (partner→RAD18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Negative regulation of mitotic sister chromatid separation →	+0.162	+0.923	<.001	<.001	3	19
SKIN	Negative regulation of sister chromatid segregation →	+0.162	+0.923	<.001	<.001	3	19
SKIN	Negative regulation of mitotic sister chromatid segregation →	+0.162	+0.923	<.001	<.001	3	19
SKIN	Negative regulation of mitotic metaphase/anaphase transition →	+0.162	+0.923	<.001	<.001	3	19
SOFT_TISSUE	Nuclear chromosome segregation →	+0.102	+1.079	.001	<.001	3	18
BREAST	Negative regulation of nuclear division →	+0.133	+1.204	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,785 associations by consensus.

Negative regulation of mitotic sister chromatid separation by RAD18 expression — SKIN

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