RAD17

Across TCGA patient cohorts, RAD17 mutation is significantly associated with the RNA expression of many other genes, with 2,948 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RAD17-associated genes across cancer lineages are APOBEC3AP1, MIR4661, and CASTOR2. Each is linked with RAD17 in more than 2 cancer types. Because this analysis shows association rather than direction, both RAD17-to-partner and partner-to-RAD17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, APOBEC3AP1 grouped by RAD17-low versus RAD17-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAD17→partner) and Y-score (partner→RAD17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	APOBEC3AP1 →	+0.235	+3.646	.001	.009	3	3
BRCA	MIR4661 →	+0.460	+5.866	<.001	.001	3	2
UCEC	CASTOR2 →	+0.753	+1.684	<.001	.003	3	2
UCEC	SRRD →	+0.383	+2.703	.002	<.001	3	2
UCEC	RTCB →	+0.527	+2.697	<.001	<.001	3	2
UCEC	MCM5 →	+0.467	+2.111	.005	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,948 associations by consensus.

APOBEC3AP1 by RAD17 expression — STAD

Explore this box plot interactively →