RAD17

Across TCGA patient cohorts, RAD17 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RAD17-associated genes across cancer lineages are ERK2, INPP4B, and p38-MAPK_pT180_Y182. Each is linked with RAD17 in more than 2 cancer types. Because this analysis shows association rather than direction, both RAD17-to-partner and partner-to-RAD17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by RAD17-low versus RAD17-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAD17→partner) and Y-score (partner→RAD17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.248	+2.906	<.001	.001	3	3
UCEC	INPP4B →	-0.287	-2.222	.010	.009	3	3
UCEC	p38-MAPK_pT180_Y182 →	-0.467	-2.057	.002	.001	3	2
UCEC	TFRC →	+0.412	+2.321	.025	.033	3	2
UCEC	ATM →	-0.367	-1.861	.019	.049	3	2
UCEC	Caspase-7-cleavedD198 →	+0.555	+1.604	.006	.021	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

ERK2 by RAD17 expression — UCEC

Explore this box plot interactively →