RAD1

Across TCGA patient cohorts, RAD1 mutation is significantly associated with the RNA expression of many other genes, with 954 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RAD1-associated genes across cancer lineages are RNA5SP412, RNA5SP415, and MTA2. Each is linked with RAD1 in more than 2 cancer types. Because this analysis shows association rather than direction, both RAD1-to-partner and partner-to-RAD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP412 grouped by RAD1-low versus RAD1-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAD1→partner) and Y-score (partner→RAD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNA5SP412 →	+0.343	+7.640	<.001	.009	3	3
BLCA	RNA5SP415 →	+0.363	+7.640	<.001	.009	3	2
UCEC	MTA2 →	+0.444	+3.515	.002	.002	3	1
UCEC	CHEK1 →	+0.638	+3.343	.004	.005	3	1
UCEC	LTO1 →	+0.314	+2.276	.005	.005	3	1
UCEC	HIRIP3 →	+0.542	+3.418	.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 954 associations by consensus.

RNA5SP412 by RAD1 expression — BLCA

Explore this box plot interactively →