RAD1

Across TCGA cell cohorts, RAD1 mutation is significantly associated with the mutation status of many other genes, with 66 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RAD1-associated genes across cancer lineages are SNAI2, M6PR, and CBX7. Each is linked with RAD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RAD1-to-partner and partner-to-RAD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNAI2 grouped by RAD1-low versus RAD1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAD1→partner) and Y-score (partner→RAD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SNAI2 →	+4.523	+5.087	.006	.006	1	1
LARGE_INTESTINE	M6PR →	+5.523	+5.523	.003	.003	1	1
LARGE_INTESTINE	CBX7 →	+5.523	+5.523	.003	.003	1	1
LARGE_INTESTINE	PSME2 →	+5.523	+5.523	.003	.003	1	1
LARGE_INTESTINE	ABHD12 →	+4.523	+5.087	.006	.006	1	1
LARGE_INTESTINE	RHOXF1 →	+4.523	+5.087	.006	.006	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 66 associations by consensus.

SNAI2 by RAD1 expression — LARGE_INTESTINE

Explore this box plot interactively →