RAC3

Across TCGA pan-cancer cohorts, RAC3 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated RAC3 data layer compared with 24 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher RAC3 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated RAC3 expression acts as an unfavorable survival marker, although some lineages such as LSCC and GBM show a favorable association.

LSCC, GBM, and LUAD are the cancer types where RAC3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	All	0.902	0.568	<.001	49	view →
GBM	DFS	Tertile	All	0.890	0.707	.015	13	view →
LUAD	OS	Tertile	II,III,IV	0.258	0.920	.003	9	view →
HNSC	DFS	Median	All	0.686	1.000	.043	4	view →
PDAC	OS	Quartile	III,IV	0.460	0.802	.024	4	view →
CCRCC	DFS	Median	III,IV	0.842	0.424	.030	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

RAC3–LSCC (DFS)

Open the LSCC breakdown →