RAC2

Across TCGA pan-cancer cohorts, RAC2 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated RAC2 data layer compared with 25 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher RAC2 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated RAC2 expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

COAD, LUAD, and HNSC are the cancer types where RAC2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Tertile	All	0.866	1.000	.032	24	view →
LUAD	DFS	Tertile	All	0.822	0.490	.002	17	view →
HNSC	DFS	Median	All	0.909	0.994	.005	10	view →
PDAC	OS	Quartile	II,III,IV	0.556	0.964	.006	10	view →
GBM	OS	Median	All	0.274	0.488	.018	8	view →
LSCC	OS	Median	II,III,IV	0.626	0.886	.022	4	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

RAC2–COAD (DFS)

Open the COAD breakdown →