RAC2

Across TCGA patient cohorts, RAC2 mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RAC2-associated genes across cancer lineages are TIGAR, MSH6, and p62 Lck ligand. Each is linked with RAC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both RAC2-to-partner and partner-to-RAC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TIGAR grouped by RAC2-low versus RAC2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAC2→partner) and Y-score (partner→RAC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TIGAR →	+0.185	+3.486	.016	.002	3	1
UCEC	MSH6 →	-0.419	-2.321	.011	.035	2	1
UCEC	p62 Lck ligand →	+0.499	+2.321	.002	.035	2	1
UCEC	Src →	+0.316	+3.169	.002	.019	2	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

TIGAR by RAC2 expression — UCEC

Explore this box plot interactively →