RAC2

Across TCGA cell cohorts, RAC2 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RAC2-associated genes across cancer lineages are ENPP6, NTSR2, and TPD52L3. Each is linked with RAC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both RAC2-to-partner and partner-to-RAC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ENPP6 grouped by RAC2-low versus RAC2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAC2→partner) and Y-score (partner→RAC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ENPP6 →	+0.049	+3.793	<.001	.007	3	1
LARGE_INTESTINE	NTSR2 →	+0.082	+3.793	<.001	.007	3	1
LARGE_INTESTINE	TPD52L3 →	+0.044	+3.684	<.001	.006	3	1
LARGE_INTESTINE	REG1B →	+3.579	+4.196	<.001	.002	3	1
LARGE_INTESTINE	NEXMIF →	+0.245	+4.196	<.001	.002	3	1
OVARY	TSPY2 →	+0.016	+5.807	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

ENPP6 by RAC2 expression — LARGE_INTESTINE

Explore this box plot interactively →