RAC1

Across TCGA pan-cancer cohorts, RAC1 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated RAC1 data layer compared with 25 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher RAC1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated RAC1 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

BLCA, ESCA, and SKCM are the cancer types where RAC1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Median	All	0.197	0.618	.017	9	view →
ESCA	DFS	Median	All	0.184	0.535	.036	6	view →
SKCM	OS	Median	III,IV	0.307	0.729	.015	5	view →
UCEC	DFS	Median	All	0.926	0.626	.039	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

RAC1–BLCA (OS)

Open the BLCA breakdown →