RAC1

Across TCGA pan-cancer cohorts, RAC1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated RAC1 data layer compared with 25 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher RAC1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated RAC1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and HNSC show a favorable association.

CCRCC, PDAC, and HNSC are the cancer types where RAC1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Quartile	III,IV	0.810	0.344	.001	34	view →
PDAC	DFS	Median	III,IV	0.381	0.870	.003	20	view →
HNSC	DFS	Median	III,IV	0.898	0.683	.010	8	view →
LSCC	OS	Tertile	II,III,IV	0.646	0.912	.012	4	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

RAC1–CCRCC (DFS)

Open the CCRCC breakdown →