RABGEF1

Across TCGA patient cohorts, RABGEF1 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RABGEF1-associated genes across cancer lineages are eEF2, GAPDH, and GATA3. Each is linked with RABGEF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RABGEF1-to-partner and partner-to-RABGEF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by RABGEF1-low versus RABGEF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RABGEF1→partner) and Y-score (partner→RABGEF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.450	+3.169	.001	<.001	3	1
UCEC	GAPDH →	+0.459	+2.999	.029	.035	3	1
UCEC	GATA3 →	+0.162	+1.598	.029	.022	3	1
UCEC	JNK_pT183_Y185 →	-0.157	-2.000	.017	.030	3	1
UCEC	MSH6 →	-0.325	-2.999	.012	.035	3	1
UCEC	NF2 →	+0.259	+2.000	.002	.030	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

eEF2 by RABGEF1 expression — UCEC

Explore this box plot interactively →