RABGEF1

Across TCGA cell cohorts, RABGEF1 mutation is significantly associated with the drug of many other genes, with 30 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RABGEF1-associated genes across cancer lineages are GSK1904529A, AZ20, and I-BET-151. Each is linked with RABGEF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RABGEF1-to-partner and partner-to-RABGEF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSK1904529A grouped by RABGEF1-low versus RABGEF1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RABGEF1→partner) and Y-score (partner→RABGEF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GSK1904529A →	+0.405	+2.678	.014	.037	3	1
LARGE_INTESTINE	AZ20 →	+0.512	+2.716	.008	.042	3	1
LARGE_INTESTINE	I-BET-151 →	+0.510	+2.777	.016	.038	3	1
LARGE_INTESTINE	JAK3_7406 →	+0.502	+2.649	.013	.046	3	1
LARGE_INTESTINE	IRAK4_4710 →	+0.364	+2.649	.046	.046	3	1
LARGE_INTESTINE	Ispinesib Mesylate →	+0.753	+2.652	.020	.045	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

GSK1904529A by RABGEF1 expression — LARGE_INTESTINE

Explore this box plot interactively →