RABGAP1

Across TCGA pan-cancer cohorts, RABGAP1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of RABGAP1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where RABGAP1 RNA is repressed in tumor relative to normal tissue. In most cancer types RABGAP1 is over-expressed in tumor, although a few such as THCA and BLCA show the opposite, repressed pattern.

THCA, LIHC, and HNSC are the cancer types where RABGAP1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RABGAP1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−1.012	<.001	10	view →
LIHC	Female	II,III,IV	+0.967	<.001	7	view →
HNSC	All	III,IV	+0.516	.002	7	view →
BLCA	Male	All	−0.695	.026	6	view →
CHOL	All	All	+1.989	<.001	5	view →
KICH	All	All	−0.738	<.001	5	view →
UCEC	All	All	−0.645	<.001	2	view →
LUAD	Female	II,III,IV	−0.387	.025	2	view →
PRAD	All	All	−0.271	.012	2	view →
KIRC	All	II,III,IV	−0.241	.023	2	view →
BRCA	Female	All	−0.152	.023	2	view →
KIRP	Male	All	−0.299	.023	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

RABGAP1–THCA

Open the THCA breakdown →