RAB8B

Across TCGA pan-cancer cohorts, RAB8B mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated RAB8B data layer compared with 21 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher RAB8B mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated RAB8B expression acts as an unfavorable survival marker, although some lineages such as HNSC and GBM show a favorable association.

PDAC, COAD, and HNSC are the cancer types where RAB8B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	III,IV	0.282	0.594	<.001	41	view →
COAD	DFS	Median	All	0.884	1.000	.018	36	view →
HNSC	OS	Tertile	All	0.941	0.804	.023	6	view →
UCEC	DFS	Quartile	All	0.822	0.973	.040	2	view →
LSCC	DFS	Median	II,III,IV	0.559	0.821	.034	2	view →
GBM	DFS	Quartile	All	0.427	0.290	.049	2	view →
CCRCC	DFS	Tertile	All	0.829	0.678	.044	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

RAB8B–PDAC (OS)

Open the PDAC breakdown →