RAB8A

Across TCGA patient cohorts, RAB8A mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RAB8A-associated genes across cancer lineages are PDCD4, 14-3-3_beta, and eEF2. Each is linked with RAB8A in more than 1 cancer types. Because this analysis shows association rather than direction, both RAB8A-to-partner and partner-to-RAB8A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by RAB8A-low versus RAB8A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAB8A→partner) and Y-score (partner→RAB8A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.544	-1.807	.005	.027	3	2
UCEC	14-3-3_beta →	-0.096	-3.143	.020	.018	3	1
UCEC	eEF2 →	+0.427	+3.321	.003	.009	3	1
UCEC	EGFR_pY1068 →	-0.378	-3.000	<.001	.001	3	1
UCEC	ERK2 →	+0.223	+2.459	.004	.019	3	1
UCEC	FOXO3a_pS318_S321 →	-0.126	-1.690	.014	.042	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

PDCD4 by RAB8A expression — UCEC

Explore this box plot interactively →