RAB7B

Across TCGA pan-cancer cohorts, RAB7B RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated RAB7B data layer compared with 5 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher RAB7B RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated RAB7B expression acts as an unfavorable survival marker, although some lineages such as LAML and MESO show a favorable association.

UVM, UCEC, and ACC are the cancer types where RAB7B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.430	0.734	<.001	124	view →
UCEC	DFS	Median	All	0.533	0.745	<.001	82	view →
ACC	OS	Quartile	II,III,IV	0.337	0.756	.004	59	view →
OV	DFS	Tertile	II,III,IV	0.153	0.230	.012	42	view →
LAML	DFS	Quartile	All	0.739	0.439	.001	42	view →
MESO	OS	Tertile	IV	0.889	0.307	.006	39	view →
LGG	OS	Tertile	All	0.672	0.861	<.001	34	view →
SARC	OS	Tertile	All	0.610	0.329	.002	19	view →
KIRP	OS	Quartile	All	0.651	1.000	.010	16	view →
SKCM	OS	Median	IV	0.867	0.225	.001	14	view →
ESCA	OS	Quartile	All	0.730	0.559	.024	14	view →
LIHC	OS	Tertile	All	0.444	0.579	.021	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

RAB7B–UVM (DFS)

Open the UVM breakdown →