Across TCGA pan-cancer cohorts, RAB6C-AS1 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated RAB6C-AS1 data layer compared with 4 for mutation status.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher RAB6C-AS1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated RAB6C-AS1 expression acts as an unfavorable survival marker, although some lineages such as BRCA and PAAD show a favorable association.

BRCA, PAAD, and UCS are the cancer types where RAB6C-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Median	All	0.949	0.897	<.001	104	view →
PAAD	DFS	Tertile	All	0.644	0.400	<.001	48	view →
UCS	DFS	Median	IV	0.367	0.952	.001	36	view →
ACC	DFS	Tertile	All	0.238	0.744	.001	36	view →
UCEC	DFS	Median	II,III,IV	0.802	0.672	.019	30	view →
LGG	OS	Median	All	0.926	0.864	.005	24	view →
CHOL	DFS	Median	All	0.689	0.113	.001	21	view →
UVM	OS	Tertile	All	0.386	0.777	.005	15	view →
LIHC	OS	Quartile	All	0.695	0.823	.012	12	view →
MESO	OS	Quartile	IV	0.868	0.434	.017	9	view →
SARC	DFS	Median	All	0.678	0.498	.021	9	view →
LUAD	DFS	Median	All	0.780	0.840	.033	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

Exploration

Same gene, other analysis: RAB6C-AS1 tumor-vs-normal RNA expression · all RAB6C-AS1 data types