RAB5IF

Across TCGA pan-cancer cohorts, RAB5IF mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated RAB5IF data layer compared with 28 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher RAB5IF mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated RAB5IF expression acts as an unfavorable survival marker, although some lineages such as COAD and LSCC show a favorable association.

COAD, CCRCC, and LSCC are the cancer types where RAB5IF mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	1.000	0.917	.021	66	view →
CCRCC	DFS	Median	III,IV	0.362	0.757	<.001	43	view →
LSCC	OS	Median	II,III,IV	1.000	0.887	.025	8	view →
HNSC	DFS	Tertile	All	0.780	0.565	.037	2	view →
LUAD	OS	Median	II,III,IV	1.000	0.807	.010	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

RAB5IF–COAD (DFS)

Open the COAD breakdown →