RAB5B

Across TCGA pan-cancer cohorts, RAB5B Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated RAB5B data layer compared with 24 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher RAB5B Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated RAB5B expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

COAD, SKCM, and CESC are the cancer types where RAB5B Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Median	All	0.056	0.871	<.001	36	view →
SKCM	OS	Median	All	0.216	0.781	.001	28	view →
CESC	DFS	Median	II,III,IV	0.144	0.705	.004	18	view →
UCEC	DFS	Median	II,III,IV	1.000	0.445	.049	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

RAB5B–COAD (OS)

Open the COAD breakdown →