RAB5B

Across TCGA pan-cancer cohorts, RAB5B mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of RAB5B’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where RAB5B mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types RAB5B is over-expressed in tumor, although a few such as HNSC and COAD show the opposite, repressed pattern.

HNSC, COAD, and LUAD are the cancer types where RAB5B tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RAB5B mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	All	−0.717	<.001	11	view →
COAD	All	IV	−0.633	<.001	11	view →
LUAD	Female	All	−0.531	<.001	9	view →
LSCC	Male	II,III,IV	−0.454	<.001	8	view →
CCRCC	All	II,III,IV	+0.104	.002	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

RAB5B–HNSC

Open the HNSC breakdown →