RAB5B

Across TCGA patient cohorts, RAB5B mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RAB5B-associated genes across cancer lineages are TFRC, EGFR_pY1068, and FoxM1. Each is linked with RAB5B in more than 1 cancer types. Because this analysis shows association rather than direction, both RAB5B-to-partner and partner-to-RAB5B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by RAB5B-low versus RAB5B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAB5B→partner) and Y-score (partner→RAB5B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TFRC →	+0.522	+3.321	.010	.009	3	2
UCEC	EGFR_pY1068 →	-0.223	-1.678	.020	.023	3	1
UCEC	FoxM1 →	+0.211	+1.678	.033	.023	3	1
UCEC	JNK2 →	+0.254	+2.817	<.001	.001	3	1
UCEC	Ku80 →	+0.209	+3.183	.020	.009	3	1
UCEC	MEK1 →	+0.427	+4.000	.002	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

TFRC by RAB5B expression — UCEC

Explore this box plot interactively →