RAB4A

Across TCGA pan-cancer cohorts, RAB4A RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of RAB4A’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where RAB4A RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RAB4A is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

LIHC, KIRC, and KICH are the cancer types where RAB4A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RAB4A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	Male	II,III,IV	+1.155	<.001	9	view →
KIRC	Female	All	+0.427	<.001	8	view →
KICH	Female	All	−1.130	<.001	7	view →
KIRP	All	II,III,IV	+0.491	.001	7	view →
LUSC	All	All	+0.416	<.001	5	view →
THCA	All	All	−0.207	.005	4	view →
CHOL	All	All	+1.053	<.001	3	view →
BRCA	All	II,III,IV	+0.141	.037	2	view →
ESCA	All	All	−0.502	.015	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

RAB4A–LIHC

Open the LIHC breakdown →