RAB4A

Across TCGA pan-cancer cohorts, RAB4A mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of RAB4A’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where RAB4A mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types RAB4A is over-expressed in tumor, although a few such as COAD and HNSC show the opposite, repressed pattern.

COAD, HNSC, and LSCC are the cancer types where RAB4A tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RAB4A mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	−0.181	<.001	7	view →
HNSC	Male	All	−0.133	.017	4	view →
LSCC	All	II,III,IV	−0.115	.001	4	view →
LUAD	Female	All	+0.179	.008	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

RAB4A–COAD

Open the COAD breakdown →