RAB43

Across TCGA pan-cancer cohorts, RAB43 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated RAB43 data layer compared with 25 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher RAB43 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated RAB43 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

COAD, CCRCC, and HNSC are the cancer types where RAB43 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	0.916	1.000	.010	36	view →
CCRCC	OS	Quartile	All	0.732	0.931	.007	10	view →
HNSC	OS	Quartile	IV	0.965	0.683	.009	8	view →
LUAD	DFS	Quartile	III,IV	0.500	0.995	.016	5	view →
LSCC	OS	Tertile	All	0.747	0.964	.013	4	view →
PDAC	DFS	Median	All	0.768	0.816	.045	3	view →
GBM	DFS	Tertile	All	0.273	0.487	.012	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

RAB43–COAD (DFS)

Open the COAD breakdown →