RAB3GAP1

Across TCGA pan-cancer cohorts, RAB3GAP1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of RAB3GAP1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where RAB3GAP1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RAB3GAP1 is over-expressed in tumor, although a few such as KICH and UCEC show the opposite, repressed pattern.

HNSC, LIHC, and KIRP are the cancer types where RAB3GAP1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RAB3GAP1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	IV	+0.736	<.001	12	view →
LIHC	Female	II,III,IV	+0.858	<.001	7	view →
KIRP	All	II,III,IV	+0.463	.007	7	view →
CHOL	Male	All	+1.783	<.001	5	view →
KICH	Female	All	−1.045	<.001	5	view →
UCEC	All	All	−0.748	<.001	4	view →
KIRC	All	All	+0.261	<.001	4	view →
THCA	All	All	−0.301	.001	3	view →
READ	Female	All	−0.540	.034	2	view →
LUSC	All	All	+0.281	<.001	2	view →
PRAD	All	All	−0.238	.032	2	view →
ESCA	Female	All	+0.913	.016	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

RAB3GAP1–HNSC

Open the HNSC breakdown →