RAB3D

Across TCGA pan-cancer cohorts, RAB3D mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated RAB3D data layer compared with 28 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher RAB3D mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated RAB3D expression acts as an unfavorable survival marker, although some lineages such as HNSC and LSCC show a favorable association.

CCRCC, COAD, and HNSC are the cancer types where RAB3D mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	All	0.601	0.943	<.001	54	view →
COAD	DFS	Median	III,IV	0.822	1.000	.020	18	view →
HNSC	DFS	Quartile	All	0.881	0.551	.005	9	view →
LUAD	DFS	Quartile	All	0.634	0.882	.010	7	view →
GBM	OS	Median	All	0.357	0.645	.010	5	view →
LSCC	OS	Tertile	All	1.000	0.687	.031	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

RAB3D–CCRCC (DFS)

Open the CCRCC breakdown →