RAB3D

Across TCGA patient cohorts, RAB3D mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RAB3D-associated genes across cancer lineages are Lck, p62 Lck ligand, and PRDX1. Each is linked with RAB3D in more than 1 cancer types. Because this analysis shows association rather than direction, both RAB3D-to-partner and partner-to-RAB3D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Lck grouped by RAB3D-low versus RAB3D-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAB3D→partner) and Y-score (partner→RAB3D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Lck →	+0.292	+3.000	.011	.037	3	1
UCEC	p62 Lck ligand →	+0.472	+2.817	.012	.036	3	1
UCEC	PRDX1 →	+0.340	+3.000	.004	.037	3	1
UCEC	Shc_pY317 →	-0.215	-3.000	.014	.037	3	1
UCEC	4E-BP1 →	+0.336	+3.000	.031	.037	3	1
UCEC	eIF4E →	+0.272	+3.000	.025	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Lck by RAB3D expression — UCEC

Explore this box plot interactively →