RAB3B

Across TCGA pan-cancer cohorts, RAB3B mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated RAB3B data layer compared with 27 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher RAB3B mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated RAB3B expression acts as an unfavorable survival marker, although some lineages such as PDAC and LSCC show a favorable association.

CCRCC, PDAC, and LSCC are the cancer types where RAB3B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	III,IV	0.405	0.936	.002	44	view →
PDAC	OS	Quartile	II,III,IV	1.000	0.663	.003	26	view →
LSCC	OS	Median	II,III,IV	0.918	0.623	.006	13	view →
HNSC	OS	Tertile	All	0.557	0.879	.009	8	view →
LUAD	OS	Median	All	0.487	0.878	.026	3	view →
UCEC	DFS	Median	All	1.000	0.854	.036	2	view →
GBM	DFS	Tertile	All	0.889	0.687	.020	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

RAB3B–CCRCC (DFS)

Open the CCRCC breakdown →