RAB3A

Across TCGA pan-cancer cohorts, RAB3A RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of RAB3A’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where RAB3A RNA is repressed in tumor relative to normal tissue. In most cancer types RAB3A is over-expressed in tumor, although a few such as KIRC and READ show the opposite, repressed pattern.

KIRC, LIHC, and KICH are the cancer types where RAB3A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RAB3A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−0.940	<.001	9	view →
LIHC	Female	All	+1.503	<.001	8	view →
KICH	Female	All	+1.386	<.001	8	view →
BRCA	All	III,IV	+1.303	<.001	6	view →
LUAD	Female	All	+0.611	<.001	6	view →
READ	All	II,III,IV	−0.750	.012	4	view →
CHOL	All	All	+1.413	<.001	3	view →
LUSC	Female	II,III,IV	+0.982	.016	2	view →
KIRP	Male	All	−0.835	<.001	2	view →
PRAD	All	All	+0.209	.034	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

RAB3A–KIRC

Open the KIRC breakdown →