RAB3A

Across TCGA pan-cancer cohorts, RAB3A mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of RAB3A’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where RAB3A mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types RAB3A is over-expressed in tumor, although a few such as CCRCC and HNSC show the opposite, repressed pattern.

CCRCC, HNSC, and COAD are the cancer types where RAB3A tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RAB3A mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Male	III,IV	−0.472	<.001	11	view →
HNSC	Male	IV	−0.733	<.001	8	view →
COAD	All	All	−1.060	<.001	5	view →
LUAD	Female	II,III,IV	+0.449	.037	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

RAB3A–CCRCC

Open the CCRCC breakdown →